Mounjaro vs Wegovy: every round scored, no favourites

On average weight loss, Mounjaro wins: in the SURMOUNT-5 head-to-head trial, people on tirzepatide lost around 20% of body weight versus around 14% on semaglutide. But "better" depends on what the judges are scoring. Wegovy starts cheaper, has the longer UK track record, and is the only one of the two with trial evidence of reduced heart attack and stroke risk in people with heart disease. Our round-by-round scoring shows where each medicine takes points — and the right choice is ultimately a decision for you and a prescriber.

At the start, clearly yes. Across the 24 regulated pharmacies we track, Wegovy's 0.25 mg starter month runs from £79.97 to £164, while Mounjaro's 2.5 mg starter runs from £145.99 to £229. At maintenance it depends on your dose: Wegovy 2.4 mg is listed from about £174.99 per 4 weeks, Mounjaro 5 mg from about £173.99, and Mounjaro's top 15 mg dose from about £288.99. Always confirm the live price on the provider's own site.

Mostly they are the same family: nausea, diarrhoea, constipation and vomiting are the most common effects of both, especially in the first weeks and after dose increases. Both list rare but serious risks including pancreatitis and gallstones. The differences sit at the margins — Wegovy's information lists NAION, a rare eye condition, while Mounjaro carries cautions around diabetic eye disease and low blood sugar when combined with certain diabetes medicines. A prescriber weighs your history against both lists.

Yes, with a prescriber managing the change. It is not a like-for-like swap: the two medicines use different dose ladders, so the prescriber selects an appropriate dose of the new medicine rather than transferring your current number across. You should never take both in the same week. Our switching guide covers the timing, what to tell the new pharmacy, and what a switch does to your monthly cost.

Yes — both Mounjaro (tirzepatide) and Wegovy (semaglutide) are prescription-only medicines in the UK. Regulated online providers typically require a BMI of 30 or more, or 27 or more with a weight-related condition, and most now ask for photo or video verification. The prescriber can decline, and a refusal is the system working. Be wary of anyone who implies approval is guaranteed.

Because it is strong in both corners. The Weight Clinic stocks Mounjaro and Wegovy, includes monthly video reviews with a clinician, refunds the consultation if you are declined, and the NEWME code takes £35 off a first order — which makes its first months among the cheapest we list (Mounjaro 2.5 mg at £125, Wegovy 0.25 mg at £80). The recommendation never changes the table order: every table on this site stays sorted by price, and no provider can pay to move up.

Every figure comes from the provider's own published pricing, and every provider listed is a GPhC-registered pharmacy or CQC-regulated clinic. Prices on this page were last checked on 4 July 2026. Pricing moves between our checks, so treat our tables as the map, and the provider's checkout as the territory — confirm before you order.